Homocysteine Plus is an updated version of our original Homocysteine Metabolite Formula. It provides the primary nutrients known to be necessary for the breakdown of homocysteine into methionine and other metabolites, including vitamin B6 as pyridoxine and pyridoxal-5’-phosphate (P5P), vitamin B12 as methylcobalamin, folate as 5-methyltetrahydrofolate (5-MTHF), trimethylglycine (TMG), and L-serine. It is now enhanced with vitamin B2 as riboflavin-5-phosphate, Setria® glutathione, zinc, and increased amounts of activated pyridoxal-5’-phosphate.
Normal homocysteine levels have been associated with cardiovascular and cognitive health, normal metabolism, and a healthy mood. Homocysteine may affect all other methyl and sulphur group metabolism processes either directly or indirectly.
Homocysteine is metabolised from the essential amino acid methionine. To prevent excess homocysteine accumulation, the body can degrade it through two pathways of liver detoxification, transsulphuration and remethylation. The transsulphuration pathway requires both pyridoxine and P5P as well as serine, and the remethylation pathway can involve methylcobalamin (the active form of B12), S-adenosyl-methionine (SAMe),5-methyltetrahydrofolate, zinc, and trimethylglycine.